Circadian mood link
In the largest genetic study of circadian rest-activity cycles in humans, scientists at the University of Glasgow have identified a possible genetic link between circadian disruption and mood disorders.
The findings, published in EBioMedicine, identified two areas of the human genome that may contain genetic variants that increase risk of disruption to rest-activity cycles.
One of these areas contained the gene Neurofascin, which binds to the protein product of a well-known candidate gene for bipolar disorder, suggesting a direct biological link between circadian disruption and severe mood disorder.
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