Features

As personalised medicine moves ever closer, we look at what’s changed in diagnostics and what the next 40 years hold During the last century we have seen enormous advances in...

Can GAGs be gagged?

November 3, 2011

William Booth discusses a new approach for high-throughput analysis of GAG interactions with growth factors and other bioregulatory proteins Glycosaminoglycans (GAGs) are a distinctive class of negatively-charged, linear polysaccharides composed...

.tb-container .tb-container-inner{width:100%;margin:0 auto} .wp-block-toolset-blocks-container.tb-container[data-toolset-blocks-container="5a8e01ead47ba4735c34df81934fa0d4"] { padding: 0px;border: 1px solid rgba( 112, 112, 112, 1 ); } .tb-container .tb-container-inner{width:100%;margin:0 auto} .wp-block-toolset-blocks-container.tb-container[data-toolset-blocks-container="a361268826fdb4abfbd23cb7c98c86ee"] { padding: 15px; } .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em} .tb-button[data-toolset-blocks-button="d15336fb035b26d1c608e0518041f8eb"] .tb-button__link { font-size: 15px;line-height: 15px; } .tb-button[data-toolset-blocks-button="d15336fb035b26d1c608e0518041f8eb"] .tb-button__icon { font-family: dashicons; } .tb-field[data-toolset-blocks-field="a38c87064193acb3d4e118731444f3e8"] { font-size: 14px;line-height: 1.5em; }  .tb-field[data-toolset-blocks-field="a38c87064193acb3d4e118731444f3e8"] a { line-height: 1.5em; } .tb-field[data-toolset-blocks-field="d090efcce1a772f31f59c379c494bcc5"] { font-size: 14px;font-weight: bold;line-height: 1.5em; }  .tb-field[data-toolset-blocks-field="d090efcce1a772f31f59c379c494bcc5"] a { line-height: 1.5em; }  .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em} .tb-button[data-toolset-blocks-button="ebbef0b0f59fe8699f5cf70d00eaf9a0"] .tb-button__link { background-color: rgba( 6, 147, 227, 1 );font-size: 14px; } .tb-button[data-toolset-blocks-button="ebbef0b0f59fe8699f5cf70d00eaf9a0"] .tb-button__icon { font-family: dashicons; }   @media only screen and (max-width: 781px) { .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   } @media only screen and (max-width: 599px) { .tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-container .tb-container-inner{width:100%;margin:0 auto}.tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   .tb-button{color:#f1f1f1}.tb-button--left{text-align:left}.tb-button--center{text-align:center}.tb-button--right{text-align:right}.tb-button__link{color:inherit;cursor:pointer;display:inline-block;line-height:100%;text-decoration:none !important;text-align:center;transition:all 0.3s ease}.tb-button__link:hover,.tb-button__link:focus,.tb-button__link:visited{color:inherit}.tb-button__link:hover .tb-button__content,.tb-button__link:focus .tb-button__content,.tb-button__link:visited .tb-button__content{font-family:inherit;font-style:inherit;font-weight:inherit;letter-spacing:inherit;text-decoration:inherit;text-shadow:inherit;text-transform:inherit}.tb-button__content{vertical-align:middle;transition:all 0.3s ease}.tb-button__icon{transition:all 0.3s ease;display:inline-block;vertical-align:middle;font-style:normal !important}.tb-button__icon::before{content:attr(data-font-code);font-weight:normal !important}.tb-button__link{background-color:#444;border-radius:0.3em;font-size:1.3em;margin-bottom:0.76em;padding:0.55em 1.5em 0.55em}   } 

MicroRNA: a primer for the cell biologist

November 1, 2011

Active in the control of cell functionality at a genetic level, through the regulation of messenger RNA transcription, miRNA is now recognised to be a powerful medium for understanding how...

Flashback

November 1, 2011

A birthday just isn’t a birthday without a good helping of nostalgia, so we thought we’d take a romp through the archives and look at some of the Highlights, lowlights...

Silk spinning the genetically modified way

October 27, 2011

Despite the huge potential of genetically modified animals outside of laboratory research, commercialisation of these animals has been extremely limited. Numerous factors, including negative consumer perception, regulatory hurdles, and limitations...

Standing the test of time

October 25, 2011

Laboratory News is not the only one celebrating 40 years; this year Gilson marks 40 years of another lab favourite. Peter Tudor takes a look back at how things have...

Real-time rapid response

October 21, 2011

With 35 deaths and thousands in hospital, time was of the essence – what was behind the recent E.coli outbreak in Germany?Genetics has entered a new era and the recent...

Beating the abundance problem

October 20, 2011

Sri Bandhakavi discusses how a novel approach to low abundance protein enrichment can enhance studies aimed at the identification of proteins and their differential analysesChanges in the abundance levels of...

The past, present and future: 40 years of genomics

October 20, 2011

One of the most amazing advances in the last 40 years of science is our insights into genomics. Since the 1970s and 1980s when Frederick Sanger established initial techniques for...

The future of medical device design

October 19, 2011

As implementation of the Third Edition of the medical electrical equipment standard draws ever closer, Jean-Louis Evans has a few pointers for developersThe transition period for the Third Edition of...

Forty years of change in the UK laboratory supply market

October 18, 2011

Forty years is a long time, but what has happened in the laboratory supply industry over that period? This article celebrates those forty years by looking at how the UK...

Speeding up cholera diagnosis

October 14, 2011

Laboratory News learns how the latest molecular diagnostics technology is helping to manage the cholera crisis in HaitiA recent study published in the Lancet predicts that there may be as...